Choline kinase
WebCholine kinase (ChoK) catalyzes the phosphorylation of choline, a key step in the biosynthesis of the membrane phospholipid phosphatidylcholine. At least three ChoK isoforms exist in mammalian cells, α-1, α-2, and β. WebNov 15, 2024 · Choline kinase (ChoK) has been well documented as a major enzyme involved in the anomalous cellular lipid metabolic profile of chronic inflammatory …
Choline kinase
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WebFeb 1, 2024 · Choline kinase α (ChoKα) is an enzyme that is upregulated in many types of cancer and has been shown to be tumorigenic. As such, it makes a promising target for inhibiting tumor growth. Though there have been several inhibitors synthesized for ChoKα, not all of them demonstrate the same efficacy in vivo, though the reasons behind this … WebFeb 3, 2024 · Modifications in enzymes controlling the catabolic and anabolic processes of phosphatidylcholine, for example, PC-specific phospholipase-C (PC-PLC), choline kinase-α (CHK α), glycerophosphocholine phosphodiesterases (GPCPDs), and PC-PLD1, are sometimes linked with the regulatory activity and actions of various choline transporters.
WebUsing 13 C-labeled choline and 13 C-magnetic resonance spectroscopy and western blotting, we show increased de novo choline phospholipid (ChoPL) production and activation of PCYT1A (phosphate cytidylyltransferase 1, choline, alpha), the rate-limiting enzyme of phosphatidylcholine (PtdCho) synthesis, during autophagy. WebMar 25, 2024 · Choline kinase-α protein and phosphatidylcholine but not phosphocholine are required for breast cancer cell survival. NMR Biomed. 28 , 1697–1706 (2015). Article CAS Google Scholar
WebNov 26, 2013 · Choline kinase-alpha expression was inhibited by specific transient RNA interference in two EOC cell lines, INTOV11 and SKOV3, with known ChoK-alpha … Choline kinase (also known as CK, ChoK and choline phosphokinase) is an enzyme which catalyzes the first reaction in the choline pathway for phosphatidylcholine (PC) biosynthesis. This reaction involves the transfer of a phosphate group from adenosine triphosphate (ATP) to choline in order to form phosphocholine. ATP … See more As of late 2007, six structures have been solved for this class of enzymes, with PDB accession codes 1NW1, 2CKO, 2CKP, 2CKQ, 2I7Q, and 2IG7. CKα-2 originating from C. elegans, is a dimeric enzyme … See more Choline kinase catalyzes the formation of phoshocholine, the committed step in phosphatidylcholine biosynthesis. Phosphatidylcholine is the major phospholipid in … See more Oncogenic activity and CKα-1 Overexpression of CKα-1 has been found to be associated with cancer. Recent studies carried out on cancer cell lines have shown that CKα-1 is over-expressed in breast cancer cells. This leads to an accumulation of … See more Although not much is known about the mechanism by which choline kinase reacts, the recent advancement in the elucidation of the … See more After closely studying the structurally similar enzymes, CKα-2, APH(3′)-IIIa, and PKA, researchers observed that PKA had less insertions to its structural core compared to the … See more Choline kinase α can act as a protein chaperone. Kinase can function as chaperone and there may be other kinases that may function as chaperone that are yet to be … See more • Hayashi SI, Lin EC (March 1967). "Purification and properties of glycerol kinase from Escherichia coli". The Journal of Biological Chemistry. 242 (5): 1030–5. PMID 5335908. • Wittenberg J, Kornberg A (May 1953). "Choline phosphokinase". The Journal of … See more
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WebFunctional Characterization of Phosphorylation of 69-kDa Human Choline Acetyltransferase at Serine 440 by Protein Kinase C eye floater that doesn\u0027t moveWebOct 15, 2024 · Choline Kinase in Eurkaryotic Cells. Choline kinase catalyzes the conversion of choline (Cho) to phosphocholine (PCho) via the transfer of a phosphate group from ATP to Cho ( Wittenberg and Kornberg, 1953 ). ChoK phosphorylation of Cho is the first step in the Kennedy pathway, which is responsible for the cell membrane component ... doerle food servicesWebMay 5, 2015 · Skeletal muscle biopsies had no detectable choline kinase (CHK) activity, consistent with a loss of function, and also showed decreased amounts of … doerksen precision products incWebFeb 7, 2016 · Abstract. Choline kinase α (CHKα) plays a crucial role in the regulation of membrane phospholipid synthesis and has oncogenic properties in vitro. We have analyzed the expression of CHKα in cell lines derived from pancreatic ductal adenocarcinoma (PDAC) and have found increased CHKα expression, associated with differentiation. CHKα … doe river fishing trailWebApr 23, 2004 · Choline kinase catalyzes the phosphorylation of choline by ATP, the first committed step in the CDP-choline pathway for phosphatidylcholine biosynthesis. To begin to elucidate the mechanism of catalysis by this enzyme, choline kinase A-2 from Caenorhabditis elegans was analyzed by systematic mutagenesis of highly conserved … doerksen peacehealth longview waWebCholine kinase (ChoKα), an essential enzyme for phosphatidylcholine biosynthesis, is required for cell proliferation and has been implicated in cancer invasiveness. Aggressive … doerle\\u0027s heating and coolingWebThe phosphorylation by choline-kinase is the first step in the Kennedy pathway which is responsible for the biosynthesis of choline phospholipids such as phosphatidylcholine (PtdCho) (18-20). PtdCho is required for the build–up and maintenance of cell membranes. It also serves as a precursor of diacylglycerol (DAG), that has an important doerle food service broussard la